0201 - Osteogenic Protein-1 Is Most Effective in Stimulating Nucleus Pulposus and Annulus Fibrosus Cells to Repair Their Matrix after Chondroitinase Abc-induced Chemonucleolysis
نویسنده
چکیده
*Takegami, K., Masuda, K., **Kumano, F., ***An, H., ****Chiba, K., ***Pankaj, D., *****Sampath, T.K., +Thonar, E.J-M.A., *Depts. of Biochemistry and Orthopedic Surgery, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, +Depts. of Biochemistry, Orthopedic Surgery and Internal Medicine, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, TEL: 312-942-5868, FAX: 312-9423053, E-mail: [email protected]
منابع مشابه
Investigation of the short-term effect of chemonucleolysis with chondroitinase ABC.
Chondroitinase ABC (C-ABC) is expected to be a novel agent for chemonucleolysis. The effect of C-ABC was investigated by magnetic resonance (MR) and radiograph. C-ABC was administered into the lumbar intervertebral disks on the clinically normal beagles (n=5), in a dose of 50 microl (12.5 units as C-ABC). MR scans were performed pre-dose, and 1, 3, 7, 14 and 28 days after administration of C-AB...
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Rabbit annulus fibrosus and nucleus pulposus were analysed for hydroxyproline, chondroitin sulphate, keratan sulphate and dermatan sulphate. Tissue proteoglycans were stained for electron microscopy with Cupromeronic blue, used in the critical electrolyte concentration mode, with and without prior digestion by chondroitinase AC or ABC, hyaluronidase or keratanase. Collagen bands, a-e were demon...
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Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to a hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (...
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Degeneration of the intervertebral disc is implicated as the main cause of low back pain. Current treatment strategies for degenerative disc disease, such as conservative treatments and surgeries, only relieve the symptoms of low back pain without treating the causes of underlying degeneration. Surgical treatments cannot reverse the degeneration of the intervertebral disc degeneration, and may ...
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